Related Experiment Video
Updated: Jun 3, 2025

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
Published on: April 10, 2018
Genetic Underpinnings of Oligoasthenoteratozoospermia
Yanting Feng1, Wensheng Liu2,3, Junbo Dong1
1School of Medicine, Yunnan University, Kunming, Yunnan, China.
Abstract:
Oligoasthenoteratozoospermia (OAT) is a frequent but severe type of male infertility. As one of the most multifaceted male infertility resulting from sperm problems, its genetic etiology remains unknown in most cases. In this review, we systematically sort out the latest literature on clinical reports and animal models leading to OAT, summarise the expression profiles of causative genes for OAT, and highlight the important role of the protein transport system during spermiogenesis, spermatid cell-specific genes, Golgi and acrosome-related genes, manchette-related genes, HTCA-related genes, and axoneme-related genes in OAT development. These causative genes would be instrumental in genetic etiological screening, genetic counseling, and pre-implantation genetic testing of patients with clinical OAT.
Related Concept Videos
Sex-linked Disorders
Infertility in Males
Oogenesis
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Nondisjunction
Spermatogenesis

