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Related Concept Videos

Oxidation of Alcohols02:37

Oxidation of Alcohols

12.7K
In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
12.7K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

9.8K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
9.8K
Radical Oxidation of Allylic and Benzylic Alcohols01:21

Radical Oxidation of Allylic and Benzylic Alcohols

1.9K
Activated manganese(IV) oxide can selectively oxidize allylic and benzylic alcohols via a radical intermediate mechanism. Primary allylic alcohols are oxidized to aldehydes, while secondary allylic alcohols yield ketones. The redox reaction of potassium permanganate with an Mn(II) salt such as manganese sulfate (under either alkaline or acidic conditions), followed by thorough drying, yields the oxidizing agent: activated MnO2. While MnO2 is insoluble in the solvents used for the reaction, the...
1.9K
Oxidation-Reduction Reactions03:11

Oxidation-Reduction Reactions

64.2K
Oxidation–Reduction Reactions
64.2K
Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate02:21

Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate

10.9K
Alkenes can be dihydroxylated using potassium permanganate.  The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.
10.9K
Oxidations of Aldehydes and Ketones to Carboxylic Acids01:15

Oxidations of Aldehydes and Ketones to Carboxylic Acids

3.7K
Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
3.7K

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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

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Recent advances in metal-catalysed oxidation reactions.

Aleena Raju1, Subhiksha Jothish1, Kokila Sakthivel1

  • 1Department of Chemistry, SAS, Vellore Institute of Technology, Chennai, Tamil Nadu 600127, India.

Royal Society Open Science
|January 9, 2025
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Metal-catalyzed oxidation reactions are essential in organic synthesis for creating valuable compounds. This review highlights key metal-catalyzed oxidation methods for producing synthetic intermediates.

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catalysisenvironment friendlymetaloxidantsoxidation

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Area of Science:

  • Organic Chemistry
  • Catalysis
  • Synthetic Chemistry

Background:

  • Oxidation reactions are fundamental in synthesizing organic compounds.
  • Key organic species like alcohols and aldehydes are oxidized to valuable intermediates.
  • These intermediates are crucial for synthesizing biologically active compounds and natural products.

Purpose of the Study:

  • To review various oxidation reactions in organic synthesis.
  • To highlight oxidation reactions specifically achieved through metal catalysis.
  • To showcase the synthetic utility of metal-catalyzed oxidation products.

Main Methods:

  • Literature review of classical and modern synthetic approaches.
  • Focus on oxidation reactions employing metal catalysts.
  • Analysis of the application of oxidation products in total synthesis.

Main Results:

  • Identification of diverse metal-catalyzed oxidation reactions.
  • Demonstration of the importance of these reactions in producing synthetic intermediates.
  • Examples of the utility of these intermediates in complex molecule synthesis.

Conclusions:

  • Metal catalysis offers powerful strategies for organic oxidation.
  • These methods are vital for accessing valuable synthetic intermediates.
  • The review underscores the significance of metal-catalyzed oxidations in modern organic synthesis.