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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Related Experiment Video

Updated: Jun 3, 2025

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
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Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

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Skin Rejuvenation Using Autologous Cultured Fibroblast Grafting.

Yoshie Hirose1, Chiharu Fujita2, Tomoka Hyoudou3

  • 1Dermatology, Ginza Yoshie Clinic, Tokyo, JPN.

Cureus
|January 9, 2025
PubMed
Summary
This summary is machine-generated.

Autologous fibroblast therapy significantly improved skin rejuvenation over three months. Patient and doctor evaluations showed increasing effectiveness, with natural improvements in texture, firmness, and wrinkles compared to hyaluronic acid injections.

Keywords:
cultured fibroblastregenerative medicineskin rejuvenationtexturewrinkle

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Area of Science:

  • Dermatology and Regenerative Medicine
  • Cell-based Therapies
  • Aesthetic Medicine

Background:

  • Autologous cultured fibroblasts and platelet-rich plasma (PRP) are used for skin rejuvenation.
  • Unlike PRP, fibroblasts offer paracrine effects, influencing surrounding tissues via cytokine release.
  • Fibroblast-derived cytokines interact with and are modulated by neighboring cells.

Purpose of the Study:

  • To evaluate the effectiveness of autologous fibroblast therapy for skin rejuvenation.
  • To assess patient and physician perceptions of treatment outcomes.
  • To compare fibroblast therapy with hyaluronic acid injections.

Main Methods:

  • Eighty-eight patients with age-related skin atrophy received facial grafts of 1x10^8 autologous cultured dermal fibroblasts.
  • Patient and doctor evaluations of treatment efficacy were conducted at one and three months post-grafting.
  • Efficacy was assessed using the last observation carried forward (LOCF) method for three-month follow-ups.

Main Results:

  • At one month, 60.3% of patients and 79.5% of doctors found the treatment effective.
  • At three months, efficacy increased to 75% for patients and 92% for doctors.
  • Fibroblast treatment demonstrated greater effectiveness at the three-month mark.

Conclusions:

  • Autologous fibroblast grafting is more effective at three months than at one month for skin rejuvenation.
  • The treatment significantly improved skin texture, addressing sagging, firmness, and wrinkles without adverse effects.
  • Fibroblast therapy provided more natural improvements compared to hyaluronic acid injections.