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Related Experiment Videos

Prolactin response to morphine in depression.

A P Zis, R F Haskett, A A Albala

    Biological Psychiatry
    |March 1, 1985
    PubMed
    Summary
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    Morphine significantly increases prolactin secretion in both healthy individuals and those with major depression. However, females showed a greater prolactin response to this opioid compared to males.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Pharmacology

    Background:

    • The opioid system is hypothesized to play a role in the pathophysiology of depression.
    • Understanding neuroendocrine responses to opioids can provide insights into mood disorders.

    Purpose of the Study:

    • To investigate the effect of morphine on prolactin secretion in unmedicated patients with major depression and healthy volunteers.
    • To compare the prolactin response between sexes and between patient groups.

    Main Methods:

    • Intravenous injection of 5 mg morphine administered to 22 unmedicated major depression inpatients and 18 healthy volunteers.
    • Blood samples collected pre-injection and at 3-hour intervals post-injection.
    • Assay of blood samples for prolactin levels.

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    Main Results:

    • Morphine administration led to a significant stimulation of prolactin secretion in all subjects.
    • Female subjects exhibited a significantly greater prolactin response compared to male subjects.
    • No significant differences in prolactin response to morphine were observed between the major depression group and the healthy volunteer group.

    Conclusions:

    • The opioid system's role in depression requires further investigation, as morphine's effect on prolactin is comparable in depressed and healthy individuals.
    • Sex differences in opioid-induced prolactin secretion are notable.
    • These findings contribute to understanding the neuroendocrine mechanisms potentially involved in depression.