Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers
Atabak Naiyeri1, Amin Moqadami1, Mohammad Khalaj-Kondori1
1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Current Gene Therapy
|January 9, 2025
Summary
Alzheimer's disease (AD) risk is linked to genetic variations. This study identifies specific gene polymorphisms, including APOE, associated with increased susceptibility to this prevalent form of dementia.
Area of Science:
- Neuroscience
- Genetics
- Dementia Research
Background:
- Dementia is a decline in cognitive functions impacting daily life.
- Alzheimer's disease (AD) is the most common and damaging form of dementia.
- The exact causes of dementia remain unknown, but genetic factors are implicated.
Purpose of the Study:
- To investigate the link between genetic polymorphism and Alzheimer's disease (AD) susceptibility.
- To identify specific genes associated with an increased risk of developing AD.
Main Methods:
- Analysis of genetic variations, including single-nucleotide polymorphisms (SNPs).
- Examination of gene polymorphisms in relation to AD risk.
- Focus on the influence of the APOE gene allele.
Main Results:
- Genetic variations in multiple genes are correlated with AD susceptibility.
- Specific gene polymorphisms identified include BDNF, PS-1, PS-2, LRP, APP, CTSD, 5-6HT, TREM2, TNF-α, LPL, CLU, SORL1, PICALM, CR1, and APOE.
- The APOE gene allele is a significant factor influencing AD.
Conclusions:
- Genetic polymorphism plays a crucial role in Alzheimer's disease (AD) risk.
- Identifying these genetic factors can contribute to understanding AD pathogenesis.
- Further research into these gene variants may offer insights into AD prevention and treatment.
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