Related Experiment Video
Updated: Jul 7, 2026
23:06
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Incipient and subclinical tuberculosis: a narrative review
1Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, Himachal Pradesh.
Summary
Tuberculosis (TB) is an airborne disease with a spectrum of infection, including early stages like incipient and subclinical TB. Early detection and treatment are crucial for the global end-TB strategy.
Area of Science:
- Infectious Diseases
- Immunology
- Public Health
Background:
- Tuberculosis (TB) is an ancient airborne infectious disease caused by Mycobacterium tuberculosis.
- Historically, TB was viewed as distinct infection or active disease, but a dynamic spectrum is now recognized.
- This spectrum includes TB infection, incipient TB, subclinical TB, and active TB disease, influenced by host and pathogen factors.
Purpose of the Study:
- To review the definition, natural history, burden, trajectory, transmissibility, detection, and management of early-stage TB.
- To highlight the importance of including incipient and subclinical TB in the end-TB strategy.
- To emphasize early diagnosis and treatment for meeting global TB elimination targets.
Main Methods:
- This review synthesizes current knowledge on early-stage TB.
- It focuses on the characteristics and progression of TB infection stages.
- Literature review and analysis of epidemiological data on TB burden and transmission.
Main Results:
- Subclinical TB, often asymptomatic, can contribute to community TB spread due to delayed diagnosis.
- Individuals with subclinical TB may remain in this stage indefinitely, progress to active disease, or even regress.
- Host and pathogen factors significantly influence an individual's position within the TB infection spectrum.
Conclusions:
- Early diagnosis and management of all stages of TB, including incipient and subclinical forms, are vital for achieving the 2035 end-TB targets.
- Understanding the dynamic spectrum of TB infection is essential for effective public health interventions.
- A comprehensive strategy must address the challenges posed by asymptomatic and subclinical TB cases to curb transmission.
More Related Videos
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Related Concept Videos
01:10Retrovirus Life Cycles
45.6K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.6K
01:29Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
01:28Pulmonary Tuberculosis II
211
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
211
01:31Pulmonary Tuberculosis III
303
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
303
01:26Pulmonary Tuberculosis IV
133
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
133
01:28Pulmonary Tuberculosis V
170
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
170