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Updated: Jun 3, 2025
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Tröger's base-embedded macrocycles with chirality
Conghao Shi1, Guangzhou Xu1, Heng Qiu1
1State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. jjl@nju.edu.cn.
This review highlights Tröger
Area of Science:
- Supramolecular Chemistry
- Organic Synthesis
- Materials Science
Background:
- Macrocycles are essential in supramolecular chemistry.
- Tröger's base (TB) offers rigidity and chirality for novel macrocycle construction.
- Synthesizing TB-embedded macrocycles is challenging due to structural strain.
Purpose of the Study:
- To review existing research on Tröger's base (TB)-embedded macrocycles.
- To explore the linkers and structure-property relationships in these macrocycles.
- To guide future synthesis of advanced TB-containing macrocycles.
Main Methods:
- Literature review of TB-embedded macrocycles.
- Analysis of synthetic challenges and linker strategies.
- Correlation of TB properties with macrocycle characteristics.
Main Results:
- Current synthesis often sacrifices TB functionality to achieve macrocyclization.
- The full potential of TB in macrocycles remains underexplored.
- Understanding linker influence is crucial for successful synthesis.
Conclusions:
- Further research is needed to overcome synthetic hurdles in TB-macrocycle construction.
- Optimizing linker design can better utilize TB's inherent properties.
- This review provides a foundation for developing superior TB-embedded macrocycles.
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