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Updated: Jun 3, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Dynamic Peptide Nanoframework-Guided Protein Coassembly: Advancing Adhesion Performance with Hierarchical Structures.

Yusai Zhou^1,2, Rong Chang³, Zhenyue Yang⁴

¹Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.

Journal of the American Chemical Society

|January 9, 2025

Summary

This summary is machine-generated.

Scientists created new bioinspired adhesives using peptide nanoframeworks and proteins. These hierarchical adhesives exhibit remarkable strength and biocompatibility for tissue repair and hemostasis.

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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Area of Science:

Biomaterials Science
Supramolecular Chemistry
Tissue Engineering

Background:

Natural adhesion systems rely on hierarchical structures, which are difficult to replicate synthetically.
Mimicking intricate molecular mechanisms and multiscale processes in synthetic adhesives presents significant challenges.

Purpose of the Study:

To develop novel complex coacervate-based adhesives with hierarchical structures.
To enable controlled regulation of cohesion and adhesion properties in engineered adhesives.
To explore the potential of these adhesives in biomedical applications.

Main Methods:

Synthesized three phosphorylated peptides with hydrophobic self-assembly motifs linked to hydrophilic phosphorylated sequences (pSGSS).
Formed peptide fibril nanoframeworks that coassemble with elastin-derived positively charged proteins (PCP).
Investigated the interfacial adhesion strength, cohesion, and biocompatibility of the resulting complex coacervate adhesives.

Main Results:

The peptide-PCP coacervates formed hierarchical structures mimicking natural adhesives.
Adhesives demonstrated tunable cohesion and adhesion properties.
The dityrosine-containing peptide and PCP complex achieved interfacial adhesion strength up to 30 MPa, rivaling chemical adhesives.
The developed adhesives exhibited promising biocompatibility and bioactivity.

Conclusions:

Bioinspired hierarchical assembly combined with bioengineering offers a powerful strategy for advancing biomedical adhesives.
These novel adhesives show potential for applications in visceral hemostasis and tissue repair.
The study demonstrates a successful approach to creating high-performance, bio-integrated adhesive materials.