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Related Experiment Video

Updated: Jun 27, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Bio-inspired approaches to in vivo DNA data storage systems.

Yi Zhang¹, Yangyi Liu², Sikang Wan¹

¹Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China. kailiu@tsinghua.edu.cn.

Materials Horizons

|June 26, 2026

Summary

In vivo DNA storage uses cells for dynamic data writing and updating, mimicking biological memory. This approach offers adaptive, autonomous data management beyond static in vitro methods.

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Last Updated: Jun 27, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

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Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Area of Science:

Biotechnology
Synthetic Biology
Bioinformatics

Background:

DNA offers high-density, stable data storage, but in vitro methods are static.
Living cells exhibit genetic memory and stimulus-responsive behaviors.
Existing DNA storage lacks dynamic data writing, updating, and self-replication capabilities.

Purpose of the Study:

To review the development of in vivo DNA storage systems.
To outline strategies for cellular DNA data management.
To explore functional integration for advanced biological data systems.

Main Methods:

Focuses on synthetic information-based storage using cellular self-replication.
Details memory-based digital recording with stimulus-responsive DNA writing.
Discusses functional integration for dynamic updating, encryption, and logical operations.

Main Results:

In vivo DNA storage leverages cells as storage and processing units.
Two core strategies enable long-term preservation and real-time data manipulation.
Functional integration expands versatility for cell-inspired information storage and computation.

Conclusions:

In vivo DNA storage presents a dynamic alternative to static in vitro systems.
Further research is needed to address challenges in storage density, editing efficiency, and cellular stability.
Future platforms aim for next-generation, cell-inspired information storage and computation.