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Time-Resolved Effects of Short-term Overfeeding on Energy Balance in Mice
Pablo Ranea-Robles1,2,3,4, Camilla Lund1, Charlotte Svendsen1
1Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Diabetes
|January 9, 2025
Abstract
Article Highlights:
Intragastric overfeeding reveals insights into the homeostatic recovery from experimental weight gain. Protection against short-term, overfeeding-induced weight gain primarily involves a profound reduction in food intake and possibly an adaptive increase in energy expenditure. UCP1-mediated thermogenesis is not essential for homeostatic protection against short-term, overfeeding-induced weight gain.
