Sleeve gastrectomy improves HDL function examined by Apo-A1 and atherogenic indices in non-diabetic obese patients

Dysregulation of lipid metabolism can be one of the pathophysiological mechanisms linking high-density lipoprotein cholesterol (HDL-C) dysfunction to obesity. The aim of the study is to show possible changes in lipid metabolism with atherogenic indices in obese patients after sleeve gastrectomy (SG) surgery.

Thirty patients who had SG surgery for obesity were included in the prospective study. The atherogenic risk indices were calculated pre-operatively, at 3 and 6 months post-operatively. Furthermore, serum paraoxonase-1 (PON-1), apolipoprotein-A1 (Apo-A1), and platelet-activating factor acetylhydrolase (PAF-AH) levels, amount of oxidized low-density lipoprotein (Ox-LDL) was measured.

We observed improvement in atherogenic risk indices and improved HDL-C functionality after SG. Increases were observed in HDL-C and HDL-C-related Apo-A1 levels 6 months after obesity surgery. Besides, the amount of serum triglycerides (TGs), PON-1 activity, and atherogenic risk indices decreased significantly within 6 months.

As far as we know, there is no study in the literature examining the dynamic changes in SG and PON-1, PAF-AH, Apo-A1, and Ox-LDL parameters. This preliminary study dynamically detected improvement in HDL-C function and reduction in atherogenic risk indices after SG.