Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Action Potential: Phases of Stimulation01:28

Action Potential: Phases of Stimulation

5.0K
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel simulation paradigm utilising MRI-derived phosphene maps for cortical prosthetic vision.

Journal of neural engineering·2023
Same author

Ocular following responses of the marmoset monkey are dependent on postsaccadic delay, spatiotemporal frequency, and saccade direction.

Journal of neurophysiology·2023
Same author

Cortical layering disrupts multi-electrode current steering.

Journal of neural engineering·2023
Same author

Connections between spatially distant primary language regions strengthen with age during infancy, as revealed by resting-state fNIRS.

Journal of neural engineering·2023
Same author

Intracortical current steering shifts the location of evoked neural activity.

Journal of neural engineering·2022
Same author

Modulation of inhibitory communication coordinates looking and reaching.

Nature·2022

Related Experiment Video

Updated: Jun 3, 2025

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

6.0K

Local field potential phase modulates the evoked response to electrical stimulation in visual cortex.

Tim Allison-Walker1,2, Maureen A Hagan2, Sabrina J Meikle2,3

  • 1School of Science, RMIT University, Melbourne, Australia.

Journal of Neural Engineering
|January 9, 2025
PubMed
Summary

Timing electrical stimulation to the local field potential (LFP) phase in the visual cortex enhances neural responses. This phase modulation approach may improve the safety and efficacy of visual prostheses.

Keywords:
cortical stimulationlocal field potentialphase modulationvisual prosthesis

More Related Videos

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
09:50

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

Published on: October 6, 2011

17.2K
Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

14.6K

Related Experiment Videos

Last Updated: Jun 3, 2025

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

6.0K
Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
09:50

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

Published on: October 6, 2011

17.2K
Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

14.6K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Visual Prosthetics

Background:

  • Cortical visual prostheses aim to restore vision by electrically stimulating the visual cortex.
  • Optimizing stimulation parameters is crucial for improving prosthesis safety, efficiency, and efficacy.
  • Local field potential (LFP) phase-dependent neural firing suggests potential for targeted stimulation.

Purpose of the Study:

  • To investigate the relationship between electrical microstimulation timing and LFP phase in the primate visual cortex.
  • To determine if phase-locked stimulation can modulate neural activity (action potentials) in V1 and V2.
  • To assess the potential of LFP phase modulation for enhancing evoked responses in visual prostheses.

Main Methods:

  • Recorded action potentials from primary (V1) and secondary (V2) visual cortex in marmosets using a 64-channel probe.
  • Delivered single-pulse electrical microstimulation at varying LFP phases in V1.
  • Analyzed evoked firing rates in V1 and V2 relative to stimulation phase and frequency.

Main Results:

  • A subset of neurons exhibited frequency-specific phase modulation of evoked responses.
  • Microstimulation in V1 at specific LFP phases increased firing rates in both V1 and V2.
  • Characterized preferred stimulation phases and frequencies for evoking responses and quantified effect size based on phase accuracy.

Conclusions:

  • Phase modulation of electrical stimulation in the visual cortex can enhance neural responses.
  • This technique holds promise for reducing stimulation charge, minimizing tissue activation, and improving visual prosthesis performance.
  • LFP phase-locked stimulation could enable more simultaneous and specific neural activation for advanced cortical visual prostheses.