Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indirect Motor Pathways01:22

Indirect Motor Pathways

1.8K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.8K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

1.3K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.3K
Feedback Inhibition00:46

Feedback Inhibition

54.9K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
54.9K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

2.3K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Local field potential phase modulates the evoked response to electrical stimulation in visual cortex.

Journal of neural engineering·2025
Same author

Dissociative and prioritized modeling of behaviorally relevant neural dynamics using recurrent neural networks.

Nature neuroscience·2024
Same author

Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device.

bioRxiv : the preprint server for biology·2024
Same author

Multimodal subspace identification for modeling discrete-continuous spiking and field potential population activity.

Journal of neural engineering·2023
Same author

Multimodal subspace identification for modeling discrete-continuous spiking and field potential population activity.

bioRxiv : the preprint server for biology·2023
Same author

Ocular following responses of the marmoset monkey are dependent on postsaccadic delay, spatiotemporal frequency, and saccade direction.

Journal of neurophysiology·2023

Related Experiment Video

Updated: Sep 26, 2025

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

1.8K

Modulation of inhibitory communication coordinates looking and reaching.

Maureen A Hagan1,2, Bijan Pesaran3

  • 1Department of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Nature
|April 21, 2022
PubMed
Summary

Neurons in the brain coordinate looking and reaching by using beta-frequency signals to temporarily suppress eye movements, enhancing reach accuracy during natural behaviors.

More Related Videos

Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

9.0K
In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.5K

Related Experiment Videos

Last Updated: Sep 26, 2025

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

1.8K
Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

9.0K
In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.5K

Area of Science:

  • Neuroscience
  • Motor Control
  • Brain Communication

Background:

  • Coordinated looking and reaching are essential for natural behaviors.
  • Understanding neural communication between brain regions is key to deciphering flexible motor control.
  • While gamma-frequency neural coherence is linked to excitatory communication, inhibitory mechanisms remain less understood.

Purpose of the Study:

  • To investigate how neurons in different brain regions communicate to enable flexible, coordinated behaviors.
  • To elucidate the mechanisms of transient neuronal suppression between brain regions during behavior.
  • To explore inhibitory communication during gaze anchoring, a behavior involving coordinated reaches and inhibited saccades.

Main Methods:

  • Studied inhibitory communication during gaze anchoring in a natural behavior task.
  • Recorded neuronal activity in the posterior parietal cortex (reach and saccade regions).
  • Analyzed neural coherence in beta-frequency (15-25 Hz) and gamma-frequency (40-90 Hz) bands.

Main Results:

  • Neurons in the reach region of the posterior parietal cortex transiently inhibit neurons in the saccade region during gaze anchoring.
  • This suppression of eye movements improves reach accuracy.
  • The inhibitory suppression is strongest when reach neurons fire in relation to beta-frequency activity, not gamma-frequency activity.

Conclusions:

  • Identified a novel mechanism of inhibitory communication involving beta-frequency neural coherence.
  • Demonstrated that beta-frequency coherence can transiently inhibit multiregional communication.
  • Provided single-neuron evidence for flexible coordination of natural behavior through targeted inhibition.