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Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
Inhibitors Of Virion Release01:25

Inhibitors Of Virion Release

Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...
Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...

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Transmitting Plant Viruses Using Whiteflies
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Complex interplay: The interactions between citrus tristeza virus and its host.

Maryam Khalilzadeh1, Dirk Jacobus Aldrich2, Hans Jacob Maree3

  • 1Citrus Research and Education Center, University of Florida, Lake Alfred, FL, USA.

Virology
|January 9, 2025
PubMed
Summary

Citrus tristeza virus (CTV) causes significant citrus diseases. Four unique CTV open reading frames (ORFs) are key to its pathogenicity and disease development in different hosts.

Keywords:
CTVQuick declineSeedling yellowsStem pittingVirus-host interactions

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Area of Science:

  • Plant Virology
  • Molecular Plant Pathology
  • Citrus Crop Science

Background:

  • Citrus tristeza virus (CTV) is a major RNA virus impacting citrus economically.
  • CTV infection leads to distinct diseases: quick decline, stem pitting, and seedling yellows.
  • CTV's genetic diversity and host-specific symptomology present research challenges.

Purpose of the Study:

  • To review the complex factors influencing Citrus tristeza virus disease induction.
  • To highlight recent advancements in understanding CTV-host interactions.
  • To elucidate the roles of specific CTV ORFs in pathogenicity.

Main Methods:

  • Functional characterization of virus-host interactions.
  • Analysis of Citrus tristeza virus genetic diversity.
  • Review of existing literature on CTV pathogenicity factors.

Main Results:

  • Four specific CTV open reading frames (ORFs)—p33, p18, p13, and p23—are critical for pathogenicity.
  • These ORFs are unique to CTV and not found in other Closteroviridae.
  • Progress has been made in understanding how these ORFs determine disease outcomes.

Conclusions:

  • Understanding CTV ORFs is crucial for managing citrus diseases.
  • Recent research offers new insights into the CTV pathosystem.
  • Further study of CTV-host interactions is vital for citrus health.