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Related Experiment Video

Updated: Jun 3, 2025

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Brain aging and rejuvenation at single-cell resolution.

Eric D Sun¹, Rahul Nagvekar², Angela N Pogson³

¹Department of Genetics, Stanford University, Stanford, CA, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA; Biomedical Informatics Graduate Program, Stanford University, Stanford, CA, USA.

|January 9, 2025

Summary

Single-cell omics reveal how brain aging affects individual cells and their interactions, offering insights into neurodegenerative diseases and potential rejuvenation strategies.

Keywords:

aging brain cell-cell interactions multi-omics regeneration rejuvenation single-cell transcriptomics spatial transcriptomics

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Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

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Last Updated: Jun 3, 2025

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Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

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Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Published on: September 14, 2015

Area of Science:

Neuroscience
Genomics
Cell Biology

Background:

Brain aging causes cognitive decline and increases vulnerability to neurodegenerative diseases like Alzheimer's and Parkinson's.
Understanding cellular changes is crucial for addressing age-related brain dysfunction.

Purpose of the Study:

To review insights from single-cell omics studies on brain aging.
To explore age-associated cellular changes, cell-cell interactions, and rejuvenation interventions.

Main Methods:

Utilizes single-cell omics technologies, including single-cell transcriptomics.
Analyzes high-dimensional profiling of individual brain cells.
Reviews existing literature on single-cell omics and brain aging.

Main Results:

Provides a cell-type-centric overview of age-related changes in the brain.
Discusses alterations in cell-cell interactions during the aging process.
Highlights the unbiased view single-cell omics offers on rejuvenation interventions.

Conclusions:

Single-cell omics offer a comprehensive understanding of brain aging at cellular resolution.
Rejuvenation interventions, particularly combinatorial approaches, show promise for brain health.
Neural stem cells are proposed as a key focus for future brain rejuvenation research.