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Concerns Regarding the Use of Kirchhoff's Laws in Pharmacokinetics
1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, USA. soie@uga.edu.
Abstract:
Over the last two years the idea that the principles presented in Kirchhoff's circuit and voltage laws also pertain to pharmacokinetics (1-3). It is claimed that these principles make the elimination in the liver and kidney more straight forward to model and provide a rationale for understanding why sometimes during bioavailability studies one arrives at bioavailability values greater than 100%. In this paper it will be shown that these claims are based on incorrect translations of the Kirchhoff's Laws to pharmacokinetics.
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