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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Two factors primarily cause thromboembolic conditions.
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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Updated: Jun 3, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Hematologic Complications of Pregnancy.

Payal Bharatkumar Patel1, Nidhi Patel2, Madeline A Hedges3

  • 1Department of Medicine, Legacy Medical Center, Portland, Oregon, USA.

European Journal of Haematology
|January 10, 2025
PubMed
Summary

Hematologic complications in pregnancy, including anemia and thrombocytopenia, require careful management. This review summarizes guidelines for common pregnancy-related blood disorders to improve maternal and fetal health outcomes.

Keywords:
iron deficiency anemiapregnancythrombocytopeniavenous thromboembolism

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Maternal-Fetal Medicine

Background:

  • Hematologic complications are frequent in pregnancy, impacting maternal and fetal well-being.
  • Clinical management is often limited by scarce evidence.
  • Key issues include iron deficiency anemia, thrombocytopenia, anemias, bleeding, and thromboembolic disorders.

Purpose of the Study:

  • To review current guidelines and management strategies for common hematologic disorders encountered during pregnancy.
  • To highlight the importance of distinguishing benign conditions from those requiring urgent intervention.

Main Methods:

  • Literature review of current guidelines and evidence.
  • Synthesis of information on the diagnosis and management of various hematologic conditions in pregnancy.

Main Results:

  • Iron deficiency anemia is the most common hematologic issue.
  • Gestational thrombocytopenia is common but usually benign; other causes require prompt treatment.
  • Inherited anemias, bleeding disorders, and thromboembolic disorders present unique challenges and risks.
  • Venous thromboembolism (VTE) is a leading cause of mortality in developed countries during pregnancy.

Conclusions:

  • Effective management of hematologic disorders in pregnancy is crucial for optimizing maternal and fetal outcomes.
  • Distinguishing between different etiologies of conditions like thrombocytopenia is vital for appropriate clinical care.
  • Adherence to current guidelines is essential for addressing the risks associated with these conditions.