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Updated: Jun 3, 2025

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Pulmonary coccidioidomycosis presenting as a fungal ball mimicking aspergilloma
Rik van den Biggelaar1, Tristan Couwenbergh1, Alexander C A P Leenders2
1Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Abstract:
A 49-year old female, known to have had an asymptomatic pulmonary cavity since 2015, presented in 2023 with hemoptysis. Radiology showed a mass suspected to be an aspergilloma. Due to persistent hemoptysis, lobectomy was performed. Pathological examination revealed fungal hyphae, and the cultured fungus was identified as a Coccidioides species by LSU sequencing. Microscopy, culture, and ITS sequencing at the national reference center confirmed the identification of Coccidioides posadasii. The patient's last visit to an endemic region was 13 years before the symptomatic disease.
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