Congenital Pulmonary Airway Malformation Associated With Papillary Adenocarcinoma

Courtney Breckenfelder1, Catherine C Dawson-Gore1, Csaba Galambos2

  • 1Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado.

Insights

This case highlights a rare instance of papillary adenocarcinoma in a 14-year-old with congenital pulmonary airway malformation (CPAM). Surgical intervention is crucial for these cystic lung lesions to rule out malignancy.

Area of Science:

  • Pulmonology
  • Thoracic Surgery
  • Pediatric Oncology

Background:

  • Congenital pulmonary airway malformations (CPAMs) are rare cystic lung lesions often diagnosed prenatally.
  • Surgical resection is frequently advised due to risks of recurrent infections and potential malignant transformation.
  • CPAMs can present with varied symptoms, sometimes leading to delayed diagnosis.

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
208
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
64
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
185