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Congenital Pulmonary Airway Malformation Associated With Papillary Adenocarcinoma
Courtney Breckenfelder1, Catherine C Dawson-Gore1, Csaba Galambos2
1Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado.
Insights
This case highlights a rare instance of papillary adenocarcinoma in a 14-year-old with congenital pulmonary airway malformation (CPAM). Surgical intervention is crucial for these cystic lung lesions to rule out malignancy.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Pediatric Oncology
Background:
- Congenital pulmonary airway malformations (CPAMs) are rare cystic lung lesions often diagnosed prenatally.
- Surgical resection is frequently advised due to risks of recurrent infections and potential malignant transformation.
- CPAMs can present with varied symptoms, sometimes leading to delayed diagnosis.
Abstract:
Congenital pulmonary airway malformations (CPAMs) are cystic lung lesions often detected prenatally. Resection is often recommended for potential recurrent infections and malignancy. This report describes a case of a 14-year-old female patient who presented with abdominal pain. A computed tomographic scan of the abdomen revealed a cystic lesion at the base of her right lung. Consequently, a computed tomographic arteriogram of the chest demonstrated a right lower lobe lesion concerning for type I CPAM. After thoracoscopic segmentectomy, histopathologic examination revealed papillary adenocarcinoma with a KRAS mutation. Residual CPAM prompted a lobectomy, emphasizing the importance of surgical intervention for cystic lesions.
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