Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foundational endovascular concepts and devices for cardiac surgeons.

JTCVS structural and endovascular·2026
Same author

Contemporary Management of the Aortic Arch: A Narrative Review.

Journal of clinical medicine·2026
Same author

The impact of left ventricular assist devices on kidney function: a systematic review and meta-analysis.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same author

From risk to results: Multi-arterial coronary bypass approaches in high-risk cohorts.

Asian cardiovascular & thoracic annals·2026
Same author

Strategies for Aortic Root Measurement in Patients Undergoing Surveillance for Thoracic Aortic Disease.

Journal of clinical medicine·2026
Same author

Clinical, Physiologic, and Anatomic Outcomes of a Novel Bioprosthetic Aortic Valved Conduit.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Jun 3, 2025

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

11.6K

A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery.

N Bryce Robinson1, Mohamed Rahouma1, Katia Audisio1

  • 1Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York.

Annals of Thoracic Surgery Short Reports
|January 10, 2025
PubMed
Summary

This study analyzed cardiothoracic surgery randomized controlled trials (RCTs) from 2008-2020. While many trials were pragmatic, few controlled for surgeon experience or monitored interventions, indicating potential quality gaps.

More Related Videos

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

1.4K
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.4K

Related Experiment Videos

Last Updated: Jun 3, 2025

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

11.6K
Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

1.4K
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.4K

Area of Science:

  • Cardiothoracic Surgery
  • Clinical Trials Methodology
  • Evidence-Based Medicine

Background:

  • Characterizing contemporary randomized controlled trials (RCTs) in cardiothoracic surgery is crucial for understanding current research practices.
  • Analysis focuses on RCTs published in high-impact journals between 2008 and 2020.

Purpose of the Study:

  • To characterize contemporary randomized controlled trials (RCTs) in cardiothoracic surgery.
  • To evaluate the quality, reporting, and design features of these trials.

Main Methods:

  • Selection of RCTs from top-tier medical, general surgery, and cardiothoracic surgery journals (2008-2020).
  • Summarization and comparison of trial characteristics, reporting standards, and quality metrics.
  • Assessment of registration, primary outcome reporting, blinding, intervention monitoring, risk of bias, funding, crossover rates, fragility index, and spin.

Main Results:

  • Ninety-three RCTs were included; 47.3% were prospectively registered, with 31.8% showing outcome discrepancies.
  • Most trials used superiority designs (89.1%) with composite primary outcomes (88.2%) and major clinical events (72.0%).
  • Infrequent blinding, lack of surgeon experience control (79.5%), high risk of bias (25.8%), and a median fragility index of 2.0 were noted. Spin was present in 17.0% of trials.

Conclusions:

  • Contemporary cardiothoracic surgery trials are largely pragmatic with low patient attrition.
  • However, few trials adequately ensured intervention quality or controlled for surgeon experience.
  • The presence of reporting spin was infrequent, but the fragility index suggests potential for results to be non-significant with minor outcome changes.