Related Experiment Video

Updated: Jun 3, 2025

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity

Wahyu Safriansyah¹, Endang Juliansyah¹, Rustaman¹

¹Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.

Journal of Asian Natural Products Research

|January 10, 2025

Abstract:

Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds 1-5 showed cytotoxic activities against MCF-7 with IC₅₀ values ranging from 160.74 to 299.75 μM.

Keywords:

Aglaia pachyphylla MCF-7 Meliaceae cytotoxic activity pachyphyllanone

More Related Videos

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

Related Concept Videos

Cycloalkanes

Cycloalkanes

Cycloalkanes are saturated cyclic hydrocarbons with carbon atoms arranged in the form of rings. They have two fewer hydrogen atoms than the corresponding acyclic alkane; therefore, their general formula is CnH2n. The structural formulas of cycloalkanes are simplified using the line-angle representation. The regular polygons are used to represent the cycloalkane rings, with each side representing a carbon-carbon bond.
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

Articles linked to this work by shared authors, journal, and citation graph.

Hepatoprotective Effects of Ethyl Acetate Extract of Lygodium microphyllum Leaves.

Iranian journal of pharmaceutical research : IJPR·2026

Optimized machine learning and artificial neural networks for NIRS-based prediction of mango internal quality.

Scientific reports·2026

Sesquiterpenoids from Dysoxylum acutangulum Miq. and Dysoxylum cauliflorum Hiern Twigs: Antibiofilm Activity Against Streptococcus mutans.

Molecules (Basel, Switzerland)·2026

Anti-inflammatory compounds from Penicillium fungi: A review.

Phytochemistry·2026

Distribution and bioactivities of tirucallane-type triterpenoids from Meliaceae family.

Natural products and bioprospecting·2026

Lansioside E, an onoceranoid-type triterpenoid isolated from the fruit peel of Lansium domesticum Corr. cv. Kokossan and its cytotoxic activity against MCF-7 breast cancer cells.

Journal of Asian natural products research·2026

See all related articles