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Evaluation of Peri-Implantitis through Fourier-Transform Infrared Spectroscopy on Saliva
Graziele Parize1, Gabrielle Luana Jimenez2, Jamil Awad Shibli3
1University of Santo Amaro (UNISA), Rua Isabel Schmidt 349, São Paulo 04743-030, Brazil.
Journal of Proteome Research
|January 10, 2025
Summary
Fourier-transform infrared spectroscopy (FTIR) can diagnose peri-implantitis by analyzing molecular changes in saliva. This method, combined with clinical data, shows promise for identifying diseased dental implants.
Area of Science:
- Biomedical Engineering
- Spectroscopy
- Dental Implantology
Background:
- Peri-implantitis involves pathological changes around dental implants.
- Fourier-transform infrared spectroscopy (FTIR) offers molecular insights for biological diagnosis.
Purpose of the Study:
- Evaluate peri-implant disease using FTIR spectroscopy with attenuated total reflectance (ATR).
- Assess the diagnostic potential of FTIR-ATR in distinguishing between healthy and diseased peri-implant tissues.
Main Methods:
- Analyzed 38 saliva samples: 17 control, 21 peri-implantitis group.
- Collected clinical data: plaque index (PI), gingival index, probing depth (PS), attachment level.
- Utilized FTIR-ATR spectroscopy in the fingerprint region for molecular analysis.
Main Results:
- Significant difference in PI between groups.
- FTIR-ATR identified key molecules: fatty acids, histidine, lipid esters, nucleic acids, tryptophan.
- A five-component partial least-squares discriminant analysis model achieved 81% accuracy in differentiating groups.
Conclusions:
- FTIR spectroscopy provides crucial molecular data for peri-implantitis diagnosis.
- Combined FTIR-ATR analysis and clinical data demonstrate effectiveness in disease detection.
- This spectroscopic technique shows potential as a diagnostic tool for peri-implant diseases.
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