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Related Concept Videos

Ethics in Research01:56

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
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From responsibility to responsibilization in stem cell research: An ethical framework.

Lars S Assen1, Annelien L Bredenoord2, Rosario Isasi3

  • 1Radboud University Medical Centre, Department of IQ Health, Kapittelweg 54, 6525 EP Nijmegen, the Netherlands; Department of Bioethics and Health Humanities, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, PO Box 8500, 3508 GA Utrecht, the Netherlands.

Stem Cell Reports
|January 10, 2025
PubMed
Summary
This summary is machine-generated.

A responsibilization approach enhances ethical stem cell (SC) research and applications. It equips SC researchers with knowledge and skills to manage the socio-ethical implications of their work.

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Area of Science:

  • Bioethics
  • Stem Cell Research

Background:

  • Ethical considerations are crucial in stem cell (SC) research and its applications.
  • Existing frameworks may not fully address the evolving ethical landscape of SC technologies.

Purpose of the Study:

  • To introduce and advocate for a responsibilization approach in SC research.
  • To outline how this approach can improve ethical conduct and manage socio-ethical implications.

Main Methods:

  • Conceptual framework development.
  • Analysis of ethical implications in SC research.
  • Focus on researcher education and organizational support.

Main Results:

  • The responsibilization approach provides a proactive strategy for ethical oversight.
  • It empowers researchers to actively engage with the societal impact of their work.
  • Aligns new and existing ethical solutions.

Conclusions:

  • Adopting a responsibilization approach is key to advancing ethical stem cell research.
  • This framework fosters a culture of shared responsibility for the socio-ethical dimensions of SC science.