Determination of total and divided clearance without blood sampling and not using a whole-body counter or gamma...

A method is suggested for the determination of total and divided clearance on the basis of one renal function-excretion. The method, which can also be used for hydronephrotic cases, does not involve blood sampling or the use of a whole-body counter or gamma camera. The method was applied to 73 patients, 14 of whom presented with hydronephrosis. Of the 73 patients, 12 were comparatively examined, and the divided clearance was simultaneously determined in three different ways: graphically, by the areas enclosed between the blood-clearance heart curve and the beginning of the secretion phase of the nephrograms; by catheterizing and measuring the excreted urine from each kidney in a well-crystal detector; by the suggested method without taking blood samples. There was good agreement between the results obtained by the last two methods.