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Phenotypic analysis of complex bioengineered 3D models.

Akhilandeshwari Ravichandran1, Vaibhav Mahajan2, Tom van de Kemp1

  • 1Centre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia; School of Mechanical, Medical, and Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.

Trends in Cell Biology
|January 10, 2025
PubMed
Summary
This summary is machine-generated.

Researchers can now create miniaturized human tissues in vitro using advanced bioengineering. This review offers tools to assess these 3D models and their responses to disease or therapies.

Keywords:
3D tissue modelsbioengineered tissuesgene and protein profilingmechanical assessmentmicroscopyphenotypic analysis

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Bioengineering

Background:

  • Advanced technologies enable the creation of in vitro miniaturized human tissues.
  • These 3D culture models mimic organotypic features of normal or diseased tissues.
  • They provide experimental access to complex tissue architectures and in vitro morphogenic assembly.

Purpose of the Study:

  • To present an analytical toolbox for researchers using 3D modeling technologies.
  • To collate currently available methods for phenotypic assessment of 3D models.
  • To evaluate 3D models in their normal state and in response to therapeutic or pathological agents.

Main Methods:

  • Review of existing analytical methods for 3D tissue model assessment.
  • Focus on phenotypic assessment techniques.
  • Inclusion of methods for evaluating responses to external agents.

Main Results:

  • A comprehensive overview of available assessment tools for 3D tissue models.
  • Methods cover both normal tissue characterization and response evaluation.
  • The toolbox aids in understanding tissue behavior in various conditions.

Conclusions:

  • 3D modeling technologies offer powerful tools for studying human tissues in vitro.
  • Phenotypic assessment is crucial for validating these models.
  • This review provides essential resources for researchers in tissue engineering and regenerative medicine.