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Nebulized Hybrid Nanoarchaeosomes: Anti-Inflammatory Activity, Anti-Microbial Activity and Cytotoxicity on A549 Cells
Sofia Giuliana Guerin Stabile1, Noelia Perez1, Horacio Emanuel Jerez1
1Centro de Investigación y Desarrollo de Nanomedicinas (CIDeN), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, B1876 Bernal, Argentina.
This study explores hybrid nanoarchaeosomes (nanoARCs) combining archaeolipids and silver nanoparticles for therapeutic applications. These nanoARCs show antimicrobial and anti-inflammatory properties, with potential to reduce reliance on conventional treatments.
Area of Science:
- Biotechnology
- Nanomedicine
- Archaeal Lipids
Background:
- Archaeolipids offer unique bilayer properties for nanocarrier development.
- Metallic nanoparticles, like silver, possess antimicrobial and therapeutic potential.
- Hybrid nanostructures can combine advantages of their constituent materials.
Purpose of the Study:
- To synthesize and characterize hybrid nanoarchaeosomes (nanoARCs) incorporating archaeolipids and biogenic silver nanoparticles (BSs).
- To evaluate the therapeutic activities, including anti-inflammatory and antimicrobial effects, of these nanoARCs.
- To assess the stability and cytotoxicity of the developed nanoARCs.
Main Methods:
- Synthesis of biogenic silver nanoparticles (BSs) using yerba mate extract.
- Preparation of two types of hybrid nanoARCs: BS-nanoARC and [BS + BS-nanoARC].
- Structural characterization (size, ζ potential) and screening of therapeutic activities (anti-inflammatory, antimicrobial, cytotoxicity).
Main Results:
- Characterized BSs (~80 nm) and hybrid nanoARCs (~100-300 nm) with distinct ζ potentials.
- BS-nanoARCs exhibited anti-inflammatory effects and potent anti-planktonic activity against *S. aureus*.
- [BS + BS-nanoARCs] showed enhanced cytotoxicity but were sensitive to storage and nebulization stress.
Conclusions:
- Hybrid nanoARCs combine archaeolipid properties with silver nanoparticle benefits for nanomedicine.
- These nanoARCs demonstrate promising antimicrobial and anti-inflammatory activities.
- Further research is needed to optimize stability for clinical applications, potentially reducing antibiotic and corticosteroid use.
