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The Physical Developmental Characterization of Children with Nutritional Deficiencies and Attributed Specific
Jingjing Liu1, Xinye Qi2, Rizhen Wang3
1School of Public Health, Anhui University of Science and Technology, Hefei 231131, China.
Insights
Nutritional deficiency diseases (NDDs) in Chinese children aged 1-7 years are linked to growth faltering, primarily due to calcium, vitamin A, and vitamin D deficiencies. These deficiencies, both single and combined, impact weight and height, underscoring the need for targeted interventions.
Area of Science:
- Pediatric Nutrition
- Public Health
- Growth and Development
Background:
- Limited research exists on the physical developmental impacts of nutritional deficiency diseases (NDDs) in Chinese children aged 1-7 years.
- Previous studies have not sufficiently clarified which specific NDD categories contribute to growth faltering.
Purpose of the Study:
- To investigate the physical developmental phenotypes of NDDs in Chinese children aged 1-7 years using anthropometric measurements.
- To identify specific NDD categories associated with growth faltering in this population.
Main Methods:
- Anthropometric data (age, height, weight) were collected from 3054 children diagnosed with NDDs.
- Data were adjusted using the skewness coefficient-median-coefficient of variation method and compared against WHO standards.
- Comparisons of specific NDD categories were made using height-for-age (HAZ), weight-for-age (WAZ), and BMI-for-age (BAZ) standardized values.
Main Results:
- Calcium, vitamin A, vitamin D, and vitamin B deficiencies were the most prevalent single NDDs.
- Protein-energy malnutrition combined with vitamin C deficiency was the most common co-occurring deficiency.
- Children with NDDs exhibited lower HAZ, WAZ, and BAZ compared to WHO standards, with WAZ showing significant differences.
- Co-morbid deficiencies, such as vitamin A and D, or calcium and C, were associated with lower WAZ.
Conclusions:
- Calcium, vitamin A, and vitamin D deficiencies are key NDDs contributing to growth issues in Chinese children.
- Growth retardation, characterized by low weight and height, is driven by single and co-morbid micronutrient deficiencies.
- Anthropometric assessment is crucial for identifying and managing NDDs and their impact on child development.
Background:
There are few studies examining the physical developmental phenotypes of nutritional deficiency diseases (NDDs) among Chinese children aged 1-7 years by anthropometrics and clarifying the specific NDD categories that caused growth faltering.
Methods:
A total of 3054 cases of NDDs in children aged 1-7 years were investigated. The age, height, and weight of children with NDDs were adjusted by using the skewness coefficient-median-coefficient of variation method, and the results were compared with the WHO standardized level. Comparisons of specific categories of NDDs were performed with respect to the age-specific height standardized values (HAZ), the age-specific weight standardized values (WAZ), and the age-specific body mass index standard values (BAZ).
Result:
The subtypes of NDDs among Chinese children were mainly characterized by single and co-morbid deficiencies. Calcium deficiency, vitamin A deficiency, vitamin D deficiency, and vitamin B deficiency were the main types, accounting for 11.33%, 9.26%, 8.70%, and 6.29% of the total confirmed cases, respectively; protein-energy malnutrition combined with vitamin C deficiency was the most common type of combined nutrient deficiency (5.76%). The HAZ (-0.0002), WAZ (-0.0210), and BAZ (-0.0018) of children aged 1-3 years with NDDs was lower than the WHO standard (0), as were the HAZ (-0.0003), WAZ (-0.0219), and BAZ (-0.0019) of children aged 3-7 years. The anthropometrics of children with NDDs aged 1-7 years showed that the HAZ and BAZ were slightly lower than the WHO average level, whereas the WAZ was significantly different from the WHO average. The co-morbidity of vitamin A deficiency and vitamin D deficiency, calcium deficiency and vitamin C deficiency, vitamin D deficiency and vitamin C deficiency, and iodine deficiency and vitamin C deficiency were associated with the WAZ.
Interpretation:
The specific categories of NDDs consist mainly of calcium deficiencies, vitamin A deficiencies, and vitamin D deficiencies. The main signs of growth retardation were low weight and height, which were driven by the specific single and co-morbid micronutrient deficiencies.
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