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Related Experiment Video

Updated: Jun 3, 2025

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

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Published on: October 23, 2021

Exploring the Link Between Obligate Anaerobe-Related Dysbiosis and Prostate Cancer Development: A Pilot Study.

Efthymios Ladoukakis¹, Tim Oliver², Mark Wilks³

¹Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

|January 11, 2025

Summary

Prostate cancer may be linked to specific bacteria, with obligate anaerobes (OAs) and Cutibacterium acnes associated with higher PSA levels. Peptostreptococcus and Ochrobactrum A were significantly linked to elevated PSA in urine samples.

Keywords:

anaerobic bacteria circumcision immune deficiency prostate cancer

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Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

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Published on: March 10, 2015

Area of Science:

Microbiology
Urology
Oncology

Background:

Prostate cancer (PCa) is increasingly linked to specific bacterial species, particularly anaerobic or microaerophilic types like Cutibacterium acnes (C. acnes).
This suggests a potential role for bacterial dysbiosis in PCa development, analogous to Helicobacter pylori's association with gastric cancer.
Prior research indicated a link between obligate anaerobes (OAs), C. acnes, and elevated prostate-specific antigen (PSA) levels.

Purpose of the Study:

To investigate the association between specific obligate anaerobic (OA) genera and prostate-specific antigen (PSA) levels in men with prostate cancer.
To identify additional bacterial taxa linked to elevated PSA levels using a data-driven approach.
To explore the potential role of bacterial dysbiosis in the early stages of prostate cancer development.

Main Methods:

Analysis of 16S rDNA sequencing data from 89 post-rectal examination urine samples of men in the PROVENT trial.
Focus on the impact of six specific OA genera: Finegoldia, Fusobacterium, Prevotella, Peptoniphilus_A, Peptostreptococcus, and Veillonella_A.
Employed a data-driven approach to uncover further associations between bacterial taxa and PSA levels.

Main Results:

A statistically significant association was found between Peptostreptococcus and elevated PSA levels.
Potential interactions were observed between Prevotella and Fusobacterium genera.
The aerobe Ochrobactrum_A also showed a significant link to higher PSA levels.

Conclusions:

Obligate anaerobic (OA)-related dysbiosis may contribute to elevated PSA levels by causing prostate cell damage, potentially preceding cancer development.
These bacterial imbalances could play a role in chronic inflammation and vascular changes in precancerous lesions.
Further clinical trials with larger cohorts are necessary to validate the role of OAs in prostate cancer pathogenesis and progression.