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Updated: Jun 3, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Correlation Between Voltage and Impedance Mapping in Patients with Atrial Fibrillation.
Antonio Taormina1, Benedetta Grossi2, Elisa Maria Ragaini2
1Cardiac Arrhythmia Department, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni, 6, 20089 Rozzano, Italy.
This study found a positive correlation between electrical impedance and voltage amplitude in atrial fibrillation ablation. This suggests impedance may help characterize the arrhythmogenic substrate during pulmonary vein isolation.
Area of Science:
- Electrophysiology
- Cardiology
- Medical Imaging
Background:
- Pulmonary vein isolation (PVI) is a key treatment for atrial fibrillation.
- Electrical impedance and voltage amplitude offer insights into tissue properties.
Purpose of the Study:
- To investigate the relationship between bipolar voltage, impedance, and left atrial wall thickness in atrial fibrillation ablation.
- To explore the potential of impedance as a tool for arrhythmogenic substrate characterization.
Main Methods:
- Prospective enrollment of patients undergoing paroxysmal (PAF) and persistent (PsAF) atrial fibrillation ablation.
- Preprocedural MDCT for left atrial wall thickness (LAWT) assessment.
- Acquisition of electroanatomic maps, collecting bipolar electrogram impedance (Ω) and voltage (mV) values.
Main Results:
- A positive correlation (rS = 0.4166, p < 0.001) was observed between bipolar voltage and impedance.
- PsAF patients exhibited lower mean impedance (129.1 ± 3.8 Ω) and voltage (<0.05 mV) compared to PAF patients.
- No significant correlation was found between voltage or impedance and LAWT.
Conclusions:
- A correlation exists between voltage amplitude and impedance values in atrial fibrillation ablation.
- Impedance may serve as a valuable parameter for characterizing the arrhythmogenic substrate.
- Further research could establish impedance as a complementary tool in PVI procedures.
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