Enhancing Corneal Sensitivity in Diabetic Patients Through an Innovative Ophthalmic Solution: In Vivo and Vitro
Fabio Scarinci1, Giovanna De Simone2, Chiara Ciancimino3
1Ophthalmology, San Giovanni-Addolorata Hospital, Via Santo Stefano Rotondo, 6, 00184 Rome, Italy.
Journal of Clinical Medicine
|January 11, 2025
Summary
This study shows a new eye drop with cross-linked hyaluronic acid (CHA), chondroitin sulfate (CS), and inositol (INS) improves dry eye symptoms and corneal sensitivity in diabetic patients. The treatment also supports corneal wound healing.
Area of Science:
- Ophthalmology
- Diabetology
- Corneal Science
Background:
- Diabetes mellitus is a significant risk factor for various corneal complications.
- These complications include dry eye, reduced corneal sensitivity, epithelial defects, and impaired wound healing.
- Effective management strategies are crucial for diabetic patients experiencing ocular surface issues.
Purpose of the Study:
- To evaluate the efficacy of a novel ophthalmic solution containing cross-linked hyaluronic acid (CHA), chondroitin sulfate (CS), and inositol (INS).
- To assess the impact of this solution on tear breakup time (TBUT), ocular surface disease index (OSDI), and corneal sensitivity in diabetic patients.
- To investigate the wound-healing potential of the CHA-CS solution in vitro.
Main Methods:
- A cohort study involving 20 diabetic patients treated with CHA-CS and 20 control diabetic patients.
- Outcome measures included tear breakup time (TBUT), OSDI scores, and corneal sensitivity assessed via Cochet-Bonnet aesthesiometry.
- In vitro scratch tests were performed on two cell lines to evaluate wound-healing properties.
Main Results:
- The CHA-CS solution significantly improved tear film stability, indicated by increased TBUT.
- Treated patients showed a reduction in dry eye symptoms (lower OSDI scores) and enhanced corneal sensitivity.
- In vitro assays demonstrated that CHA-CS promotes cell motility, supporting tissue repair.
Conclusions:
- The CHA-CS ophthalmic solution shows promise as an innovative treatment for diabetic-induced corneal alterations.
- It effectively addresses dry eye symptoms, improves corneal sensitivity, and aids in wound healing.
- This novel formulation offers a potential therapeutic option for managing ocular complications in diabetes.
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