Related Experiment Video
Updated: Jun 3, 2025
07:57
Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
3.9K
Approach to Lipid Management in the Patient With Diabetes
Stephanie Kim1, Savitha Subramanian2
1Assistant Professor of Clinical Practice Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109, USA.
The Journal of Clinical Endocrinology and Metabolism
|January 11, 2025
Summary
Diabetes elevates atherosclerotic cardiovascular disease (ASCVD) risk, driven by dyslipidemia. Managing lipids with statins and newer therapies is crucial for reducing ASCVD events in diabetic patients.
Area of Science:
- Cardiology
- Endocrinology
- Metabolic Diseases
Background:
- Diabetes mellitus significantly increases atherosclerotic cardiovascular disease (ASCVD) risk.
- Dyslipidemia, characterized by hypertriglyceridemia and altered cholesterol levels, is a key driver of ASCVD in diabetic individuals.
- Current guidelines recommend statin therapy for ASCVD risk reduction in diabetes.
Purpose of the Study:
- To review the pathogenesis of dyslipidemia in type 1 and type 2 diabetes.
- To provide an update on current lipid management strategies for individuals with diabetes.
- To discuss the role of add-on therapies and glycemic-lowering agents in cardiovascular risk reduction.
Main Methods:
- Literature review of pathogenesis and management of dyslipidemia in diabetes.
- Analysis of current clinical guidelines and emerging therapeutic options.
- Discussion of risk stratification and individualized treatment approaches.
Main Results:
- Dyslipidemia in diabetes involves hypertriglyceridemia, low HDL-C, and small, dense LDL particles.
- Statins are foundational for ASCVD risk reduction in diabetic patients.
- Novel add-on therapies offer further cardiovascular protection beyond statins.
Conclusions:
- Effective management of dyslipidemia is essential for mitigating ASCVD risk in diabetes.
- Individualized treatment selection, risk stratification, and avoiding therapeutic inertia are critical.
- Glycemic-lowering therapies can have significant lipid-related effects that warrant consideration.
Related Concept Videos
01:15Diabetes: Management and Pharmacotherapy
233
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
233
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
529
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
529
01:24Overview of Lipid Metabolism
1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K
01:22Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
01:22Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
01:18Lipids: Dietary Sources and Requirements
681
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
681