Antifungal activity of different extractions of drone larvae (apilarnil)

Drone larvae (DL) has many biological activities thanks to the bioactive components it contains, but there are very few studies on its antimicrobial activity. The aim of this research was to determine the antifungal activity of DL (raw and lyophilised) water and ethanol extracts against fluconazole (FLU) sensitive and resistant yeast strains. The 87 fungal strains obtained from clinical samples were identified by phenotypic and molecular methods, and broth microdilution test was used for antifungal activity. All DL extracts had antifungal activity. The ethanolic extract of lyophilised DL showed higher antifungal activity. Total phenolic substance content and antioxidant activity of lyophilised DL ethanolic extract were found to be higher than other extracts. According to these results, the observed antifungal activity of DL extracts can be attributed not only to phenolic components, but also to synergistic effect of phenolic components with other bioactive components it contains.