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Published on: February 9, 2019
Recent advances in lipid-based nanocarriers for advanced skin cancer therapy
Mohd Shoab Ali1, Mohammad Ali Abdullah Almoyad2, Shadma Wahab3
1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062 India.
Abstract:
Skin cancer is prevalent worldwide,surpassing all other forms of cancer and it does not respond effectively to conventional formulations. Treatment of skin cancer further require deeper permeation into the skin. Therefore, researchers are working on different types of nanoformulations for delivering therapeutic agents to the site of action. Amongst, lipid-based nanoparticles have shown potential for the efficient delivery of drugs to skin tumors, where properties like biocompatible, non-toxic, and biodegradable have attracted researcher concern. The literature revealed that these lipid-mediated nanocarriers with a size < 100 nm treats skin cancer efficiently and surmount resistance by increasing the solubility and stability of the hydrophobic chemotherapeutics. These lipid nanocarriers are safer for topical application and facilitate permeation through the skin by interacting with the lipid bilayer membranes, resulting in rearrangement of them to promote penetration into the cells. This review discussed the research done so far to treat skin cancer with lipid-based nanocarriers. These nanocarriers can be effective tools, which can be explored and established further to combat the increasing incidences of skin cancer in the future.
Insights
Lipid-based nanoparticles offer a promising solution for treating skin cancer, enhancing drug delivery and permeation. These nanocarriers effectively treat skin tumors and overcome resistance, showing potential for future skin cancer therapies.
Area of Science:
- Nanotechnology
- Dermatology
- Oncology
Background:
- Skin cancer is a prevalent global health issue, often resistant to conventional treatments.
- Effective skin cancer therapy necessitates enhanced drug permeation deep into the skin layers.
- Conventional formulations struggle to deliver therapeutic agents efficiently to the tumor site.
Purpose of the Study:
- To review the current research on lipid-based nanocarriers for skin cancer treatment.
- To highlight the potential of nanocarriers in improving drug delivery and efficacy for skin malignancies.
- To discuss the advantages of lipid nanocarriers in overcoming treatment resistance and enhancing skin penetration.
Main Methods:
- Literature review of studies utilizing lipid-based nanocarriers for skin cancer therapy.
- Analysis of nanocarrier properties, including size, biocompatibility, and biodegradability.
- Examination of mechanisms for enhanced drug solubility, stability, and skin permeation.
Main Results:
- Lipid-based nanocarriers (<100 nm) demonstrate efficient delivery of drugs to skin tumors.
- These nanocarriers increase the solubility and stability of hydrophobic chemotherapeutics, surmounting resistance.
- Lipid nanocarriers facilitate topical application and enhance skin permeation by interacting with lipid bilayers.
Conclusions:
- Lipid-based nanocarriers are effective tools for treating skin cancer.
- Their biocompatible and biodegradable nature makes them suitable for topical drug delivery.
- Further exploration and establishment of these nanocarriers can combat rising skin cancer incidences.
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