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Published on: May 31, 2016
Risk factors for radial artery calcification in patients with and without uremia
Jian-Bing Hao1, Si-Yu Wang2, Tong Chen2
1Department of Nephrology, Southern University of Science and Technology Hospital, Shenzhen, China. haojianbing@sustech-hospital.com.
Insights
Vascular calcification in uremic patients is linked to radial artery stenosis. Key factors like allograft inflammatory factor 1 (AIF-1), parathyroid hormone (PTH), and FGF23 were identified as significant risk factors in this study.
Area of Science:
- Nephrology
- Vascular Biology
- Biochemistry
Background:
- Radial artery calcification is a primary cause of anastomotic stenosis in arteriovenous fistulas for uremic patients.
- The exact mechanisms driving vascular calcification in uremia remain unclear.
- This research aimed to identify and confirm risk factors for vascular calcification in individuals with uremia.
Purpose of the Study:
- To screen and validate risk factors for radial artery calcification in uremic patients.
- To investigate the association between serum biochemical indicators and calcification.
- To analyze the expression of calcification-related molecules in the radial artery.
Main Methods:
- Collected serum and radial artery tissue from 60 uremic patients (with or without hemodialysis).
- Measured general biochemical indicators and calcification-related molecules using ELISA and correlation analysis.
- Evaluated pathological changes and molecule expression via HE and immunohistochemical staining.
Main Results:
- Significant differences observed in serum calcium, phosphorus, allograft inflammatory factor 1 (AIF-1), intact parathyroid hormone (iPTH), vitamin D (VD), fibroblast growth factor 23 (FGF23), and soluble klotho (sKlotho) between uremic patients with and without hemodialysis.
- These factors demonstrated a correlation with radial artery calcification.
- Elevated expression of AIF-1, PTHR1, VDR, FGF23, and sKlotho was noted in calcified radial artery tissues.
Conclusions:
- Serum levels of AIF-1, PTH, VDR, FGF23, and sKlotho are associated with radial artery calcification in uremic patients.
- Abnormalities in calcium and phosphorus metabolism exacerbate radial artery calcification in patients undergoing maintenance hemodialysis.
Background:
Calcification of the radial artery is one of the main causes of anastomotic stenosis in autogenous arteriovenous fistulas in uremic patients. However, the pathogenesis of calcification is still unknown. This study attempted to screen and validate the risk factors for vascular calcification in patients with uremia.
Methods:
Serum of blood were collected and tissue samples from radial artery were obtained from 60 uremia patients with or without hemodialysis. General biochemical indicators and calcification-related molecules were collected and detected via ELISA or correlation analysis. In addition, pathological changes and calcification-related molecules in the radial artery were evaluated by HE or immunohistochemical staining.
Results:
There were differences in total calcium, calcium-phosphorus products, allograft inflammatory factor 1 (AIF-1), intact parathyroid hormone (iPTH), vitamin D (VD), fibroblast growth factor 23 (FGF23) and soluble klotho (sKlotho) in the blood of uremic patients with or without hemodialysis. Furthermore, these factors are related to calcification of the radial artery. The expression of AIF-1, PTHR1, VDR, FGF23 and sKlotho was also increased in the calcified radial artery.
Conclusions:
The levels of AIF-1, PTH, VDR, FGF23 and sKlotho in serum were associated with calcification of the radial artery in patients with uremia. Furthermore, calcification of the radial artery was further aggravated by abnormalities in calcium and phosphorus in maintenance hemodialysis patients.
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