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Psychotic-Spectrum Disorders With Comorbid Anxiety Are Predisposing Factors for Parkinson's Disease in a Case-Control
Anna Shvartsur1, Kelli Peterman2, Nirmala D Ramalingam3
1Department of Psychiatry, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.
The Permanente Journal
|January 12, 2025
Summary
Psychotic-spectrum disorders, especially with anxiety, significantly increase Parkinson's disease (PD) risk. Early awareness of these psychiatric conditions can help identify individuals at higher risk for PD development.
Area of Science:
- Neurology
- Psychiatry
- Epidemiology
Background:
- Growing evidence links psychiatric conditions to Parkinson's disease (PD) development.
- Research on psychotic-spectrum disorders preceding PD is limited.
Purpose of the Study:
- To evaluate the prevalence of psychotic-spectrum disorders, with and without anxiety and depression, before a PD diagnosis.
- To assess the association between these psychiatric conditions and subsequent PD diagnosis.
Main Methods:
- Retrospective case-control study involving adults over 60 years old.
- PD cases and controls (3:1 ratio) identified from ambulatory encounters (2015-2020).
- Psychiatric conditions identified via diagnosis codes up to five years prior to PD diagnosis; conditional logistic regression used.
Main Results:
- Individuals with psychotic-spectrum diagnoses had 76% higher odds of developing PD.
- Comorbid anxiety diagnosis further increased PD odds by 166%.
- The study analyzed data from 13,998 patients.
Conclusions:
- Psychiatric conditions, particularly psychotic-spectrum disorders with anxiety, are significant risk factors for PD.
- Identifying these comorbidities can help stratify individuals at increased risk for Parkinson's disease.
- Enhanced awareness of psychiatric comorbidities may aid in early PD risk assessment.
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