Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extrapulmonary silicosis: a clinical, morphologic, and ultrastructural study.

R E Slavin, J L Swedo, D Brandes

    Human Pathology
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Segmental Arterial Mediolysis in Pigs Presenting With Renal Infarcts.

    Veterinary pathology·2015
    Same author

    Myocardial toxicity in a group of greyhounds administered ractopamine.

    Veterinary pathology·2011
    Same author

    Mortality due to lung cancer in Mexico.

    Lung cancer (Amsterdam, Netherlands)·2007
    Same author

    Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD.

    The American journal of psychiatry·2001
    Same author

    Successful treatment of feline pancreatitis using an endoscopically placed gastrojejunostomy tube.

    Journal of the American Animal Hospital Association·2001
    Same author

    Dimension reduction and source identification for multispecies groundwater contamination.

    Journal of contaminant hydrology·2001
    Same journal

    TRPS1 and GATA3 Expression in BRG1/SMARCA4-deficient Malignant Neoplasms.

    Human pathology·2026
    Same journal

    Clinicopathologic and Molecular Characteristics of Acral Melanomas Harboring RARA Fusions.

    Human pathology·2026
    Same journal

    Clinical Impact of Second Opinion Consultation in Bladder Biopsies and Transurethral Resection of Bladder Tumors.

    Human pathology·2026
    Same journal

    Prognostic relevance and molecular correlates of Claudin-1 expression in pancreatic neuroendocrine tumors.

    Human pathology·2026
    Same journal

    Mixed Phenotype Acute Leukemia: Lineage Assignment, Immunophenotypic Classification and Genetic Insights.

    Human pathology·2026
    Same journal

    Chronic myelomonocytic leukemia revisited: A comprehensive review with emphasis on the oligomonocytic subtype.

    Human pathology·2026
    See all related articles

    Silicosis, a lung disease, can spread to other organs, causing varied lesions. These lesions involve macrophage activity, fibrosis, and collagen changes, potentially leading to kidney and autoimmune issues.

    Area of Science:

    • Pathology
    • Toxicology
    • Immunology

    Background:

    • Thoracic silicosis can disseminate to extrapulmonary sites via lymphohematogenous spread.
    • Silicotic lesions exhibit diverse morphology influenced by macrophage activity, fibrogenesis, and matrix degradation.

    Purpose of the Study:

    • To describe the morphologic features of silicotic lesions in extrapulmonary organs.
    • To elucidate the ultrastructural changes in collagen and extracellular matrix within silicotic lesions.
    • To investigate potential remote effects of silicosis, including glomerulonephritis and autoimmune phenomena.

    Main Methods:

    • Morphologic examination of silicotic lesions in liver, spleen, bone marrow, and lymph nodes.
    • Ultrastructural analysis of collagen fibril alterations and matrix deposition.

    Related Experiment Videos

  • Correlation of lesion morphology with clinical findings, including renal and autoimmune parameters.

    • Main Results:

    • Silicotic lesions in extrapulmonary organs vary based on macrophage aggregation, fibrosis, and necrosis.
    • Ultrastructural changes include collagen fibril splitting and the formation of fibrous long-spacing collagen.
    • Fibrinoid necrosis and sclerohyaline nodules are characteristic features, with variations in spleen and liver.
    • Glomerulonephritis occurred in 40% of cases, and lymphocyte destruction may contribute to autoimmune reactions.

    Conclusions:

    • Silicosis induces complex morphologic changes in extrapulmonary tissues, involving matrix remodeling and collagen alteration.
    • The characteristic sclerohyaline nodule evolves through distinct histiocytic phases.
    • Extrapulmonary silicosis may be associated with significant renal and autoimmune complications.