Graphene oxide-based fluorescent biosensors for pathogenic bacteria detection: A review

Area of Science:

• Nanotechnology
• Biochemistry
• Analytical Chemistry

Background:

• Pathogenic bacteria pose significant public health risks, necessitating rapid and sensitive detection methods.
• Fluorescent biosensors offer high sensitivity, specificity, and stability for bacterial detection.
• Graphene oxide (GO) is increasingly utilized in fluorescent biosensors due to its unique properties.

Purpose of the Study:

• To systematically review the development of graphene oxide (GO)-based fluorescent biosensors for pathogenic bacteria detection.
• To discuss functionalization, modification, design, and signal amplification strategies for GO-based fluorescent biosensors.
• To explore challenges and future perspectives in GO-based fluorescent sensing technologies.

Main Methods:

• Review of literature on graphene oxide (GO) functionalization and modification.
• Analysis of design principles and signal amplification strategies for GO-based fluorescent biosensors.
• Exploration of current challenges and future research directions in the field.

Main Results:

• Graphene oxide (GO) significantly enhances the performance of fluorescent biosensors.
• Various functionalization and modification techniques improve GO's suitability for biosensing.
• Effective design and signal amplification strategies are crucial for sensitive detection.

Conclusions:

• GO-based fluorescent biosensors represent a promising platform for high-performance pathogenic bacterial assays.
• Further development can aid in preventing the spread of multidrug-resistant bacteria.
• This review provides insights to advance GO-based fluorescent sensing technologies.