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Viruses and neurodegeneration: a growing concern
S Shouman1, N Hesham1,2, T Z Salem3,4
1Biomedical Sciences Program, UST, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza, 12578, Egypt.
Journal of Translational Medicine
|January 12, 2025
Summary
Viral infections may trigger or worsen neurodegenerative diseases (NDDs). This review explores the link between viruses and NDDs, examining neuroinflammation and potential treatments.
Area of Science:
- Neurology
- Virology
- Immunology
Background:
- Neurodegenerative diseases (NDDs) involve progressive neuron loss with multifactorial causes.
- Epidemiological and clinical studies suggest a link between viral infections and NDD onset or progression.
- Understanding viral neuropathogenesis is crucial for NDD research.
Purpose of the Study:
- To review the neuropathic effects of viruses from multiple perspectives.
- To explore the role of neuroinflammation in viral neuropathogenesis.
- To discuss potential treatments and challenges for virus-associated NDDs.
Main Methods:
- Literature review of epidemiological, clinical, and biological studies.
- Classification of viruses and associated NDDs.
- Analysis of cellular pathways involved in viral neuropathogenesis.
Main Results:
- Neuroinflammation, triggered by viral infections, is a key factor in neuropathogenesis.
- Both neurotropic and non-neurotropic viruses can induce neuroinflammation.
- The COVID-19 pandemic has raised questions about vaccine roles in NDDs.
Conclusions:
- Establishing the precise link between viruses and NDDs requires further investigation.
- Insights into viral neuropathogenesis can advance diagnostic and therapeutic strategies.
- Continued research is essential for managing virus-associated neurodegenerative conditions.
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