Related Experiment Video
Updated: Jun 3, 2025
08:58
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
15.9K
A Very Low-Carbohydrate Program in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease and
Laura R Saslow1, Jamie Krinock1, Alison O'Brien1
1Department of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, MI, United States.
JMIR Formative Research
|January 13, 2025
Summary
A very low-carbohydrate (VLC) diet intervention shows promise for reducing liver fat and weight in individuals genetically predisposed to metabolic dysfunction-associated steatotic liver disease. The study highlights the diet
Area of Science:
- Metabolic health and genetic predisposition.
- Nutritional interventions for liver disease.
Background:
- Insulin resistance and the rs738409 G allele increase the risk of metabolic dysfunction-associated steatotic liver disease (MASLD).
- Genetic factors play a role in MASLD development.
Purpose of the Study:
- To investigate the efficacy of a very low-carbohydrate (VLC) dietary pattern in reducing insulin resistance.
- To assess the impact of a VLC diet on liver steatosis and metabolic markers in at-risk individuals.
Main Methods:
- Adults with the rs738409-GG or -CG genotype, liver steatosis, and elevated liver function tests received a 4-month VLC diet intervention.
- Intervention included education on VLC eating, mindful eating, goal setting, and self-monitoring with coaching.
- Measurements included liver steatosis, anthropometrics, serum metabolic markers, diet adherence, and quality of life.
Main Results:
- High intervention satisfaction was reported, with many participants intending to continue the VLC diet.
- Adherent participants showed a significant reduction in liver fat (53.12%).
- All participants achieved significant weight loss (≥5%), and 75% met responder criteria for liver fat reduction.
Conclusions:
- The VLC dietary intervention appears feasible, acceptable, and demonstrates preliminary efficacy in adults at genetic risk for MASLD.
- Further research is warranted due to the small sample size and potential for bias in this pilot study.
Keywords:
liver function testT2DMadultdietary patterngenomegenotypeinsulininsulin resistanceketogenic dietlow carbohydratemetabolic dysfunctionmetabolic dysfunction–associated steatotic liver diseasenon-alcoholic fatty liver diseasesingle-arm pilot trialtype 2 diabetesMore Related Videos
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
767
04:14Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
11.9K
Related Concept Videos
01:24Overview of Lipid Metabolism
997
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
997
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
130
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
130
01:29Cholesterol: Significance and Regulation
499
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
499
01:20Inborn Errors of Metabolism
125
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
125
01:29Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
526
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
526