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Updated: Jun 3, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

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Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma

Elena N Voropaeva1,2, Yuriy L Orlov3,4, Anastasia B Loginova2

  • 1Research Institute of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution "The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences", Novosibirsk, Russia.

Peerj
|January 13, 2025
PubMed

Insights

Dysregulation of p53-responsive microRNAs (miRNAs) is implicated in diffuse large B-cell lymphoma (DLBCL) development. Understanding these molecular mechanisms offers new avenues for miRNA-based diagnostics and therapeutics in DLBCL.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNAs play critical roles in carcinogenesis, acting as oncogenes or tumor suppressors.
  • The p53 tumor suppressor protein influences cellular stress responses, including miRNA expression.

Purpose of the Study:

  • To discuss the molecular mechanisms of p53-responsive microRNA dysregulation in diffuse large B-cell lymphoma (DLBCL).
  • To explore the role of microRNAs in p53-mediated cellular stress and oncogenesis.
  • To highlight opportunities for miRNA-based diagnosis, prediction, and therapy in DLBCL.

Main Methods:

  • Overview of microRNA biogenesis and the role of p53.
  • Analysis of molecular mechanisms causing miRNA dysregulation in DLBCL.
  • Review of studies on miRNA roles in tumorigenesis, focusing on tumor suppression.

Main Results:

  • Genotoxic stress in DLBCL involves dysregulation of p53-responsive microRNAs.
  • Mechanisms include TP53 gene mutations, DNA methylation, altered host gene expression, and copy number variations.
  • Mutations in miRNA genes and their biogenesis pathways also contribute to dysregulation.

Conclusions:

  • Understanding miRNA dysregulation in DLBCL provides insights into oncogenesis.
  • miRNA-based approaches show promise for DLBCL diagnosis and treatment.
  • Bioinformatics tools and databases are crucial for advancing DLBCL research on microRNAs.
Keywords:
Diffuse Large B-cell Lymphoma (DLBCL)Gene expressionmicroRNA regulationmicroRNA-based cancer therapyp53 response elements

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