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A Real-World Evidence Primer for Advanced Practice Providers: Integrating P-Reality X Into Shared Decision-Making for
Sarah Donahue1, Joanne C Ryan2, Kimberly Podsada3
1From UCSF Health, San Francisco, California.
Journal of the Advanced Practitioner in Oncology
|January 13, 2025
Summary
Advanced practice providers will increasingly use real-world data (RWD) studies alongside randomized controlled trials (RCTs). Understanding RWD study methods and integrating evidence is crucial for oncology clinical practice and patient decision-making.
Area of Science:
- Oncology
- Health Informatics
- Clinical Research
Background:
- Advanced practice providers in oncology increasingly encounter real-world data (RWD) studies.
- Real-world evidence (RWE) from RWD offers insights into therapeutic effectiveness beyond randomized controlled trials (RCTs).
Purpose of the Study:
- To provide an overview of fundamental aspects of RWD studies.
- To outline requirements for conducting robust RWD studies.
- To demonstrate how RWD studies complement RCTs in oncology.
Main Methods:
- Literature review of recently published RWD studies.
- Discussion of methodologies for conducting RWD studies.
- Analysis of RWD study interpretation and integration with RCT data.
Main Results:
- RWD studies provide valuable evidence on treatment effectiveness in real-world settings.
- Understanding RWD study conduct is essential for clinical application.
- RWD studies can complement and enhance findings from RCTs.
Conclusions:
- RWD studies are integral to modern oncology practice.
- Interpreting and integrating RWD with RCT data supports clinical decision-making.
- Robust RWD study design is key to generating reliable real-world evidence.
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