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Overcoming drug resistance through extracellular vesicle-based drug delivery system in cancer treatment

Long Zheng1,2,3,4, Ruibai Chang1,2,3,4, Bingjing Liang2,3,4

  • 1College of Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

Cancer Drug Resistance (Alhambra, Calif.)
|January 13, 2025
PubMed

Insights

Engineered extracellular vesicles (EVs) offer a novel approach to overcome cancer drug resistance. These natural nanoparticles enhance drug delivery, reduce toxicity, and target cancer cells, paving the way for improved cancer therapies.

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Nanotechnology

Background:

  • Drug resistance is a significant obstacle in cancer treatment, leading to therapy failure and relapse.
  • Conventional chemotherapies and targeted treatments often become ineffective due to acquired cancer drug resistance.
  • Extracellular vesicles (EVs) are emerging as promising nanocarriers for drug delivery due to their biocompatibility and targeting capabilities.

Purpose of the Study:

  • To review the characteristics and functionalization of EVs for drug delivery.
  • To discuss the mechanisms underlying cancer drug resistance.
  • To explore the application of engineered EVs in overcoming drug resistance.

Main Methods:

  • Literature review of current research on EVs in cancer therapy.
  • Analysis of EV properties relevant to drug delivery and overcoming resistance.
  • Discussion of strategies for engineering EVs for enhanced therapeutic efficacy.

Main Results:

  • EVs can be engineered to improve drug loading, targeting specificity, and cellular uptake.
  • EV-based drug delivery systems show potential in enhancing drug accumulation at tumor sites.
  • Engineered EVs can mitigate systemic toxicity associated with conventional cancer treatments.

Conclusions:

  • Engineered EVs represent a promising strategy to overcome cancer drug resistance.
  • EV-based drug delivery systems have the potential to revolutionize cancer therapy.
  • Further research into EV functionalization and clinical translation is warranted for effective cancer treatment modalities.
Keywords:
Extracellular vesiclescancer therapydrug delivery systemsdrug resistancetumor microenvironment

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