Related Experiment Video
Updated: Jun 2, 2025
Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Helicobacter pylori gastritis in Jordanian children: persistence versus resolution
Eyad Altamimi1, Lma Salameh2, Hanin AlNsour2
1Paediatric Department, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Insights
Helicobacter pylori (H. pylori) infection is common in children, often causing abdominal pain. Older age and milder symptoms may increase the chance of H. pylori infection resolution.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Helicobacter pylori (H. pylori) is a primary cause of infectious gastritis, frequently acquired in childhood.
- Understanding the clinical and pathological aspects of H. pylori infection in pediatric populations is crucial for effective management.
Purpose of the Study:
- To characterize pediatric patients diagnosed with H. pylori infection.
- To compare clinicopathological features between children with resolved and persistent H. pylori infections.
Main Methods:
- Retrospective review of pediatric patients with biopsy-proven H. pylori infection over six years.
- Analysis of hospital electronic records, endoscopic databases, and histopathology findings.
- Comparison of data for patients who underwent follow-up endoscopy.
Main Results:
- 176 pediatric patients were identified; 56.2% were female, with an average age of 10.2 years.
- Recurrent abdominal pain was the most common symptom (51.69%).
- Only 23.81% of patients with follow-up showed H. pylori resolution, with older children being more likely to resolve the infection.
Conclusions:
- H. pylori infection in children frequently presents with abdominal pain.
- Factors such as female gender, older age, and less severe macroscopic/microscopic findings may correlate with a higher likelihood of infection resolution.
Introduction:
Helicobacter pylori (H. pylori) is the most common cause of infectious gastritis. Helicobacter pylori is an infection that is typically acquired during childhood.
Aim:
This study aims to describe children with H. pylori infection and compare the clinicopathological features of children with resolved and persistent infection.
Material And Methods:
This is a retrospective review of all children with biopsy-proven H. pylori infection over a 6-year period. Hospital electronic files, endoscopic database, and histopathology database were reviewed. Patients who underwent follow-up endoscopy were identified, and their data was compared.
Results:
A total of 176 patients were identified, of whom 100 (56.2%) were females. The average age at presentation was 10.2 years (range: 2.5-17 years). Children older than 10 years were the most affected age group. The most commonly presenting symptom was recurrent abdominal pain (92 (51.69%)), followed by epigastric pain/dyspepsia and vomiting (44 (24.72%) and 18 (10.11%), respectively). The most common macroscopic feature was antral nodularity (76 (42.70%)). The most prevalent microscopic findings were moderate inflammation of moderate chronicity. None of the patients developed gastric atrophy. Forty-four (23.5%) patients had comorbid diseases. On follow-up, upper endoscopy was available for 42 (23.59%) patients. The resolution of H. pylori based on histological examination was observed in only 10 (23.81%) patients. Children whose infections resolved were older.
Conclusions:
A significant number of children with biopsy-proven H. pylori infection presented with abdominal pain. Female gender, older age, and less severe macroscopic and microscopic findings may be associated with a higher chance of infection resolution.
More Related Videos
04:56Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis
Published on: May 16, 2025
03:47Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
Related Concept Videos
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
01:26Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...