Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonlinear Redox-Immune Coupling Under Low-Dose-Rate Radiation: A Compartment-Specific Framework for Biological Responses-A Narrative Review.

Antioxidants (Basel, Switzerland)·2026
Same author

Understanding Spaceflight-Induced Oxidative Stress and the Critical Role of Diet and Microbiome.

Antioxidants (Basel, Switzerland)·2026
Same author

Real-world effectiveness of bortezomib maintenance following VMP induction in transplant-ineligible multiple myeloma: a target trial emulation study.

Annals of hematology·2026
Same author

Cumulative Low-Dose-Rate Radiation Induces Oxidative Stress, Apoptosis, and Fibrosis in Mouse Testis.

Antioxidants (Basel, Switzerland)·2025
Same author

Co-Expression of TWIK-Related Acid-Sensitive K<sup>+</sup> Channel 1 (TASK-1/KCNK3) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRα/Pdgfra) in Adult Mouse Ovary.

Biomedicines·2025
Same author

Immunometabolic Signatures in Chronic DILI: An Integrated and Translational Perspective.

Journal of gastroenterology and hepatology·2025

Related Experiment Video

Updated: Jul 7, 2026

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.2K

Sea Hare Hydrolysate Reduces PD-L1 Levels in Cancer Cells and Mitigates Rheumatoid Arthritis Ina Collagen-Induced

Ji Hyeon Ryu1, Min Seok Song2,3, Marie Merci Nyiramana2,4

  • 1Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan Republic of Korea.

Food Science & Nutrition
|January 13, 2025
PubMed
Summary

Sea hare hydrolysate (SHH) reduces cancer cell PD-L1 levels and treats rheumatoid arthritis (RA) by decreasing inflammation. SHH shows promise as an immune-oncology (I-O) agent without RA exacerbation risks.

Keywords:
PD‐L1arthritiscancerimmunotherapysea hare hydrolysate

More Related Videos

Detecting Migration and Infiltration of Neutrophils in Mice
10:33

Detecting Migration and Infiltration of Neutrophils in Mice

Published on: February 6, 2020

11.9K
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.1K

Related Experiment Videos

Last Updated: Jul 7, 2026

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.2K
Detecting Migration and Infiltration of Neutrophils in Mice
10:33

Detecting Migration and Infiltration of Neutrophils in Mice

Published on: February 6, 2020

11.9K
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.1K

Area of Science:

  • Immunology
  • Oncology
  • Rheumatology

Background:

  • Previous research indicated sea hare hydrolysate (SHH) has anticancer properties by inhibiting signal transducer and activator of transcription 3 (STAT3), affecting macrophage polarization and pyroptosis in lung cancer.
  • Immune-oncology (I-O) agents, like those targeting programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1), can increase rheumatoid arthritis (RA) risk.
  • Investigating SHH's effects on PD-L1 and its potential as an I-O agent or adjuvant, considering RA as a potential side effect, is crucial.

Purpose of the Study:

  • To evaluate the impact of SHH on PD-L1 expression across diverse cancer cell types.
  • To assess SHH's therapeutic efficacy in a collagen-induced arthritis (CIA) mouse model, mimicking RA.
  • To determine if SHH can serve as an immune-oncology (I-O) agent or adjuvant with a favorable safety profile regarding RA.

Main Methods:

  • SHH was applied to various cancer cell lines to measure PD-L1 levels.
  • A collagen-induced arthritis (CIA) mouse model was used to evaluate SHH's anti-inflammatory effects compared to methotrexate (MTX).
  • Arthritis scores, paw thickness, anti-collagen type II (CII) antibodies, pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), and histopathological changes were assessed.

Main Results:

  • SHH significantly reduced PD-L1 levels in multiple cancer cell lines and decreased PD-1/PD-L1 in tumor-associated macrophages.
  • In the CIA mouse model, SHH demonstrated anti-inflammatory effects comparable to MTX, significantly lowering arthritis scores and paw thickness.
  • SHH treatment reduced elevated anti-CII antibodies and pro-inflammatory cytokines, mitigating arthritic inflammation, synovial hyperplasia, and cartilage/bone loss.

Conclusions:

  • SHH effectively decreases PD-L1 levels in cancer cells and exhibits significant anti-inflammatory properties in a preclinical RA model.
  • SHH's therapeutic effects in CIA are comparable to methotrexate, suggesting its potential as a treatment for inflammatory conditions.
  • SHH shows promise as an immune-oncology agent or adjuvant, potentially offering therapeutic benefits without the risk of exacerbating RA.