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In vivo itaconate tracing reveals degradation pathway and turnover kinetics

Hanna F Willenbockel, Alexander T Williams, Alfredo Lucas

    Biorxiv : the Preprint Server for Biology
    |January 13, 2025
    PubMed
    Summary

    Itaconate, an immunomodulatory metabolite, is rapidly cleared from circulation and metabolized in the liver and kidneys. This study reveals its in vivo degradation kinetics and impact on cellular metabolism.

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