Lanthanide-Assisted Function Tailoring of the HOF-Based Logic Gate Sensor Array for Biothiol Detection and Disease...

Area of Science:

• Materials Science
• Analytical Chemistry
• Biomedical Engineering

Background:

• Early cancer diagnosis relies on detecting specific biomarkers.
• Biothiols like GSH, Cys, and Hcy are crucial cancer indicators.
• Existing biosensors often face challenges with sensitivity and specificity.

Purpose of the Study:

• To develop a lanthanide-based sensor array for discriminating key biothiols.
• To enable sensitive and accurate detection of cancer biomarkers.
• To create a platform for early cancer diagnosis.

Main Methods:

• Designed a lanthanide-based covalent organic framework (HOF) composite sensor array.
• Utilized tailored lanthanide functions for targeted emission responses.
• Employed machine learning algorithms for data analysis and discrimination.

Main Results:

• The sensor array successfully discriminated between different biothiols (GSH, Cys, Hcy).
• Achieved nearly 100% accuracy in classifying clinical liver cancer samples.
• Demonstrated high sensitivity and low self-fluorescence interference.

Conclusions:

• Lanthanide 'personality function tailoring' in HOFs offers a robust biosensing strategy.
• The developed sensor array shows significant potential for early cancer detection.
• This approach enhances the suitability of biosensors for clinical applications.