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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
Published on: September 27, 2019
Triphase Interfacial Nucleation Enables Microneedle-Templated Metal-Organic Framework Coating for In Situ DNA Capture
Fangling Wang1, Shuang Miao1, Le Tang2
1Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.
Analytical Chemistry
|June 18, 2026
Summary
Researchers developed a new method for growing metal-organic framework (MOF) particles directly onto microneedles. This technique improves molecule capture from biofluids for advanced in situ biosampling.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Immobilizing porous metal-organic framework (MOF) particles on microneedles aids in situ biofluid sampling.
- Current methods like homogeneous nucleation yield poor adhesion and density, and can damage substrates.
Purpose of the Study:
- To develop a novel strategy for in situ growth of MOFs on microneedles.
- To achieve uniform, dense, and robust MOF particle coverage for enhanced biosampling.
Main Methods:
- A triphase interfacial heterogeneous nucleation strategy using water-based solvents under ambient conditions.
- Utilizing solvent evaporation at the gas-liquid interface and Marangoni flow to control MOF growth.
- Demonstrating the method across multiple MOF species and on UiO-66 MOF functionalized microneedles.
Main Results:
- Achieved uniform, dense, and robust MOF particle coverage on polymeric microneedles.
- MOF-functionalized microneedles demonstrated enhanced selective DNA capture and elution.
- Microneedles showed durability through cyclic liquid immersion and plant leaf insertion.
Conclusions:
- The triphase interfacial heterogeneous nucleation strategy enables controlled MOF growth on microneedles.
- MOF-functionalized microneedles represent a significant advancement for on-site biosampling technologies.
- This approach enhances molecular capture and elution efficiency for various applications.
