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Adaptive Coacervate Microreactors with Broad pH/Thermal Tolerance for Reaction Acceleration
Fei Zhang1, Yanan Wei1, Tianyue Ma1
1Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.
JACS Au
|July 30, 2026
Summary
This study shows abiological coacervates can act as microreactors, enhancing reaction rates by 14.5-fold. These coacervates maintain stability across wide temperature and pH ranges, ideal for biocatalysis.
Area of Science:
- Supramolecular chemistry
- Chemical engineering
- Biochemistry
Background:
- Coacervate microdroplets accelerate reactions via electrical fields or confined environments.
- Product accumulation within coacervates can disrupt local conditions and reaction stability.
Purpose of the Study:
- To investigate the stability and reaction-enhancing capabilities of abiological coacervates.
- To explore the dynamic thermal and pH adaptability of coacervate microreactors.
Main Methods:
- Formation of abiological coacervates via polycation-multivalent anion interactions.
- Enzyme cascade reactions within coacervates to assess buffering and stability.
- Measurement of reaction rates under varying temperature and pH conditions.
Main Results:
- Coacervates tolerated external temperatures of 19-41 °C and pH 4-11.
- Internal heat generation increased fluidity, boosting production rate by 14.5-fold.
- Coacervates buffered internal pH oscillations, stabilizing enzyme conformations.
Conclusions:
- Abiological coacervates serve as adaptable microreactors with enhanced reaction rates.
- Dynamic thermal and pH adaptability ensures consistent enzyme performance.
- Coacervate microreactors show potential for industrial biocatalysis and precision medicine.
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