Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

27.2K
Overview
27.2K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Antibody Structure01:10

Antibody Structure

58.9K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
58.9K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

236
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
236
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

346
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
346
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular metabolism of substance P produces neurokinin-1 receptor peptide agonists with diminished cyclic AMP signaling.

American journal of physiology. Cell physiology·2024
Same author

Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes.

Cells·2021
Same author

Histamine receptors in heart failure.

Heart failure reviews·2021
Same author

The Histamine 3 Receptor Is Expressed in the Heart and Its Activation Opposes Adverse Cardiac Remodeling in the Angiotensin II Mouse Model.

International journal of molecular sciences·2020
Same author

The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.

International journal of molecular sciences·2020
Same author

Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart.

Scientific reports·2019
Same journal

Expression Landscape and Circadian Regulation of lncRNAs in the Kidney.

Acta physiologica (Oxford, England)·2026
Same journal

A Mouse Ladder-Climb Protocol Induces Acute Anabolic Signaling and Muscle-Specific Adaptations to Resistance Training.

Acta physiologica (Oxford, England)·2026
Same journal

RyR1 Calcium Leak and Mitochondrial Ca<sup>2+</sup> Homeostasis in Skeletal Muscle.

Acta physiologica (Oxford, England)·2026
Same journal

Functional Differences in Electrolyte Transport Between the Mouse Proximal and Distal Trachea.

Acta physiologica (Oxford, England)·2026
Same journal

Of Mice and Men: Toward Mouse-Specific Diastolic Echocardiography.

Acta physiologica (Oxford, England)·2026
Same journal

Myosin Post-Translational Modifications Associated With Critical Illness Myopathy.

Acta physiologica (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2025

Detection of True IgE-expressing Mouse B Lineage Cells
09:40

Detection of True IgE-expressing Mouse B Lineage Cells

Published on: December 1, 2014

10.9K

IgE and cardiac disease.

Scott P Levick1

  • 1Department of Physiology, Pharmacology and Toxicology, West Virginia University, Morgantown, West Virginia, USA.

Acta Physiologica (Oxford, England)
|January 13, 2025
PubMed
Summary
This summary is machine-generated.

Immunoglobulin E (IgE) is linked to heart disease, particularly myocardial infarction. Research explores whether IgE causes cardiac issues or results from them, impacting allergy and cardiovascular health.

Keywords:
allergyheart failureischemiamast cellmyocardial infarction

More Related Videos

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.4K
Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor Fc&#949;RI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

12.4K

Related Experiment Videos

Last Updated: Jun 2, 2025

Detection of True IgE-expressing Mouse B Lineage Cells
09:40

Detection of True IgE-expressing Mouse B Lineage Cells

Published on: December 1, 2014

10.9K
Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.4K
Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor Fc&#949;RI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

12.4K

Area of Science:

  • Immunology
  • Cardiology
  • Allergy Research

Background:

  • Immunoglobulin E (IgE) is key in immediate hypersensitivity (anaphylaxis) and chronic allergic reactions.
  • Clinical studies link serum IgE levels to myocardial infarction and ischemic cardiac events.
  • Animal models suggest IgE can promote atherosclerotic plaque formation.

Purpose of the Study:

  • To review clinical studies on IgE levels and cardiac disease, especially myocardial infarction.
  • To discuss animal studies elucidating IgE's chronic cardiac effects.
  • To investigate whether IgE is a cause or a consequence of cardiac disease.

Main Methods:

  • Review of clinical investigations on serum IgE and cardiac events.
  • Analysis of animal model studies on IgE's role in cardiac pathology.
  • Synthesis of evidence to address IgE's etiological role in heart disease.

Main Results:

  • A clear association exists between IgE levels and ischemic cardiac events, particularly myocardial infarction.
  • Conflicting evidence from animal and clinical studies regarding IgE's role in atherosclerosis (causative vs. protective).
  • Animal models indicate IgE may have adverse effects in non-ischemic cardiac disease.

Conclusions:

  • IgE's relationship with cardiac disease is complex, with potential roles in both causation and response.
  • Further research is needed to clarify IgE's specific mechanisms and clinical implications in cardiovascular health.
  • Understanding IgE's dual role is crucial for managing allergic and cardiovascular conditions.