Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fermented food microbiome: influence on oral and gut microbiota, and human health.

Nature reviews. Microbiology·2026
Same author

Solvent-triggered reconfiguration of optical physical unclonable functions.

Nature communications·2026
Same author

Extreme Nanoconfinement Dramatically Enhances Small Molecule Solubility in Nonpolar Polymers.

ACS nano·2026
Same author

Correction: Scalable flow synthesis of ultrasmall inorganic nanoparticles for biomedical applications via a confined impinging jet mixer.

Scientific reports·2026
Same author

Recent advances in nanoalloys for selective electrochemical CO<sub>2</sub> reduction.

Nanoscale advances·2026
Same author

Translational Research to Maximize the Impact of e-Oral Health.

JDR clinical and translational research·2026

Related Experiment Video

Updated: Jul 5, 2026

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

7.9K

Robotic Microcapsule Assemblies with Adaptive Mobility for Targeted Treatment of Rugged Biological Microenvironments.

Hong Huy Tran1,2,3,4, Zhenting Xiang1,2,4, Min Jun Oh1,2,3,4

  • 1Center for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

ACS Nano
|January 13, 2025
PubMed
Summary

New microrobots navigate complex biological environments for targeted drug delivery. Hierarchical assembly enables self-reconfigurable microcapsule collectives with enhanced mobility and cargo protection for advanced biomedical applications.

Keywords:
collective behaviorcolloidal roboticsdouble emulsionsfungal infectionmicrorobotsmodular microrobotstargeted delivery

More Related Videos

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.3K
Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly
10:17

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

3.1K

Related Experiment Videos

Last Updated: Jul 5, 2026

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

7.9K
Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.3K
Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly
10:17

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

3.1K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Robotics

Background:

  • Current magnetic microrobots face limitations in navigating complex biological terrains due to challenges in engineering intersubunit interactions.
  • Solid monolithic particle microrobots lack the collective adaptability needed for irregular environments and confined spaces.

Purpose of the Study:

  • To design and develop hierarchically assembled microrobots with multiaxis mobility and collective adaptability.
  • To engineer stable, self-reconfigurable microrobot structures capable of carrying and protecting cargo internally for biomedical applications.

Main Methods:

  • Utilized double emulsion templates and magnetic control to create multiunit robotic collectives from microcapsules containing iron oxide and silica nanoparticles.
  • Engineered potential magnetic interaction energy between subunits to achieve stable, self-reconfigurable structures.
  • Investigated the effect of asymmetric nanoparticle localization on intercapsule potential energy and stability under rotating magnetic fields.

Main Results:

  • Demonstrated that asymmetric iron oxide nanoparticle localization enhances intercapsule potential energy, creating stable connections without altering magnetic susceptibility.
  • Observed emergent behaviors in microcapsule collectives, including self-reconfiguration into kinematic chain-like structures for traversing complex obstacles and rugged tissues.
  • Successfully demonstrated targeted antifungal delivery to a localized biofilm model on mucosal tissues, effectively killing Candida without damaging host cells.

Conclusions:

  • Hierarchical assembly enables the creation of cargo-carrying microrobots with collective, self-adaptive mobility for navigating complex biological environments.
  • These microrobots offer a promising platform for advancing targeted drug delivery and noninvasive biomedical procedures.
  • The developed microrobots overcome limitations of current systems in traversing challenging biological terrains and confined spaces.